Investigating the Quantitative Nature of MALDI-TOF MS

MALDI-TOF MS in Prenatal Genomics.

Prenatal diagnosis aims either to provide the reassurance to the couples at risk of having an affected child by timely appropriate therapy or to give the parents a chance to decide the fate of the unborn babies with health problems. Invasive prenatal diagnosis (IPD) is accurate, however, carrying a risk of miscarriage. Non-invasive prenatal diagnosis (NIPD) has been developed based on the exist...

Dossier MALDI - TOF ■ Oligonucleotide analysis by MALDI - MS

Matrix-assisted laser desorption (MALDI) time-offlight (TOF) mass spectrometry (MS) has been successfully used for oligonucleotide sequence confirmation by mass analysis of fragments generated by concentration-dependent exonuclease digestion. This approach is particularly well-suited to the analysis of synthetic DNA due to the relatively short length of the DNA strands. Additionally, an importa...

Characterization of fengycin homologues produced by Bacillus subtilis K1 by MALDI-TOF tandem mass spectrometry (MALDI TOF MS/MS)

Evaluation of MALDI-TOF MS in the microbiology laboratory

First submission on 22/12/12; last submission on 22/10/12; accepted for publication on 12/12/12; published on 20/06/13 1. Master degree in Infectious Diseases by Universidade Federal de São Paulo (UNIFESP). 2. PhD in Infectious Diseases by UNIFESP; attending post-doctorate at UNIFESP and laboratory supervisor at ALERTA laboratory from UNIFESP Infectious Disease Department. 3. Infectious Disease...

The application of MALDI-TOF MS for dermatophyte identification.

Dermatophytes are keratinolytic fungi responsible for a wide variety of diseases of the skin, nails and hair of mammals. Their identification is often complicated, labor-intensive and time consuming due to the high degree of intra-species morphological similarity, and also requires scientific knowledge and practice. The aim of this study was to demonstrate that MALDI-TOF MS technique may be a f...